Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation
نویسندگان
چکیده
منابع مشابه
Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.
BACKGROUND A massive destruction of transplanted tissue occurs immediately following transplantation of pancreatic islets from pig to non-human primates. The detrimental instant blood-mediated inflammatory reaction (IBMIR), triggered by the porcine islets, is a likely explanation for this tissue loss. This reaction may also be responsible for mediating an adaptive immune response in the recipie...
متن کاملIslet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation.
OBJECTIVE In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently id...
متن کاملDual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood-mediated inflammatory reaction (IBMIR). This syndrome of islet destruction has been incompletely defined and characterization in pig-to-primate models has been hampered by logis...
متن کاملα-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction
Islet cell transplantation has limited effectiveness because of an instant blood-mediated inflammatory reaction (IBMIR) that occurs immediately after cell infusion and leads to dramatic β-cell death. In intraportal islet transplantation models using mouse and human islets, we demonstrated that α-1 antitrypsin (AAT; Prolastin-C), a serine protease inhibitor used for the treatment of AAT deficien...
متن کاملCharacterizing the Mechanistic Pathways of the Instant Blood-Mediated Inflammatory Reaction in Xenogeneic Neonatal Islet Cell Transplantation
INTRODUCTION The instant blood-mediated inflammatory reaction (IBMIR) causes major loss of islets after transplantation and consequently represents the initial barrier to survival of porcine neonatal islet cell clusters (NICC) after xenotransplantation. METHODS This study used novel assays designed to characterize the various immunologic components responsible for xenogeneic IBMIR to identify...
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ژورنال
عنوان ژورنال: Xenotransplantation
سال: 2008
ISSN: 0908-665X,1399-3089
DOI: 10.1111/j.1399-3089.2008.00482.x